Multiple distinct O-Mannosylation pathways in eukaryotes
نویسندگان
چکیده
منابع مشابه
O-mannosylation of cadherins.
Two reports in PNAS by Vester-Christensen et al. (1) and Lommel et al. (2) provide critical new insight into how a unique family of glycans contributes to early embryonic development, brain development, and malignant transformation. Following transfer of mannose (Man) to Ser or Thr by protein Omannosyltransferase (POMT), either POMT1 or POMT2, the O-Man can be further modified with N-acetylgluc...
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In eukaryotes, Dom34 upregulates translation by securing levels of activatable ribosomal subunits. We found that in the yeast Saccharomyces cerevisiae and the human fungal pathogen Candida albicans, Dom34 interacts genetically with Pmt1, a major isoform of protein O-mannosyltransferase. In C. albicans, lack of Dom34 exacerbated defective phenotypes of pmt1 mutants, while they were ameliorated b...
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The mammalian O-mannosylation pathway for protein post-translational modification is intricately involved in modulating cell-matrix interactions in the musculature and nervous system. Defects in enzymes of this biosynthetic pathway are causative for multiple forms of congenital muscular dystophy. The application of advanced genetic and biochemical technologies has resulted in remarkable progres...
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Genomic clustering of genes in a pathway is commonly found in prokaryotes due to transcriptional operons, but these are not present in most eukaryotes. Yet, there might be clustering to a lesser extent of pathway members in eukaryotic genomes, that assist coregulation of a set of functionally cooperating genes. We analyzed five sequenced eukaryotic genomes for clustering of genes assigned to th...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2019
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2019.03.003